El-Beshlawy, A., Youssry, I., El-Saidi, S., El, Accaoui R., Mansi, Y., Makhlouf, A., and Taher, A. 2012;5:CD007280. Fathizadeh H, Milajerdi A, Reiner Z, Kolahdooz F, Asemi Z. Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. View abstract. 1979;43(2):300-306. Acta Haematol. Kavukcu, S., Turkmen, M., Salman, S., Onvural, B., Oktay, G., Karaman, O., and Cevik, N. T. The effects of L-carnitine on respiratory function tests in children undergoing chronic hemodialysis. [Ref], Very common (10% or more): Hypercalcemia (15%), hypervolemia (12%), Common (1% to 10%): Anorexia, hyperkalemia[Ref], Very common (10% or more): Pain (35%), flu syndrome (29%), chest pain (15%), accidental injury (12%), asthenia (12%), fever (12%), Common (1% to 10%): Peripheral edema, weight decrease, weight increase, Very rare (less than 0.01%): Body odor, International Normalized Ratio (INR) increased[Ref], Very common (10% or more): Injection site reaction (38%)[Ref], Musculoskeletal side effects, in chronic hemodialysis patients, for levocarnitine (the active ingredient contained in L-Carnitine) in relation to placebo therapy have included asthenia (8% to 12% vs 8%) and leg cramps (4% to 8% vs 13%). Karalis DT, Karalis T, Karalis S, Kleisiari AS. View abstract. View abstract. Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. 2009;24(1):27-33. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. 2002;4(1):61-66. View abstract. View abstract. Influence of L-carnitine administration on maximal physical exercise. Molyneux, R., Seymour, A. M., and Bhandari, S. Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies. Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature. Crill, C. M., Christensen, M. L., Storm, M. C., and Helms, R. A. Call your doctor for medical advice about side effects. Am J Clin.Nutr 2009;89(1):71-76. Clinical Trials Journal 1986;23(4):242-248. View abstract. eCollection 2019. View abstract. 2010;38:152-5. It has been reported to cause vomiting, diarrhea, a fishy body odor, abdominal cramps, and nausea. Ho, J. Y., Kraemer, W. J., Volek, J. S., Fragala, M. S., Thomas, G. A., Dunn-Lewis, C., Coday, M., Hakkinen, K., and Maresh, C. M. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. Pola P, Savi M, Grilli M, and et al. The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. Zhonghua Nan.Ke.Xue. 2011;46(6):750-759. Touati, G., Valayannopoulos, V., Mention, K., de, Lonlay P., Jouvet, P., Depondt, E., Assoun, M., Souberbielle, J. C., Rabier, D., Ogier de, Baulny H., and Saudubray, J. M. Methylmalonic and propionic acidurias: management without or with a few supplements of specific amino acid mixture. Endocr.J 2010;57(9):777-786. J Int.Soc.Sports Nutr. Abbasnezhad A, Hasanavand A, Falahi E, Kashkooli S, Asbaghi O, Choghakhori R. Effect of L-carnitine supplementation on lipid profiles of patients with liver disease: a systematic review and meta-analysis. Dig.Dis. De Simone C, Catania S, Trinchieri V, and et al. Rossignol, D. A. and Frye, R. E. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Eur Heart J 1996;17:414-20. Heinonen OJ. For your body to produce it in sufficient amounts, you also need plenty of vitamin C (4). Applies to levocarnitine: capsule, capsule liquid filled, solution, tablet. Ann.Pharmacother. A pilot study. View abstract. Cruciani, R. A., Dvorkin, E., Homel, P., Culliney, B., Malamud, S., Lapin, J., Portenoy, R. K., and Esteban-Cruciani, N. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study. Basic Clin Pharmacol Toxicol. Fatouros, I. G., Douroudos, I., Panagoutsos, S., Pasadakis, P., Nikolaidis, M. G., Chatzinikolaou, A., Sovatzidis, A., Michailidis, Y., Jamurtas, A. Pons-Rejraji H, Brugnon F, Sion B, Maqdasy S, Gouby G, Pereira B, Marceau G, Gremeau AS, Drevet J, Grizard G, Janny L, Tauveron I. Rathod, R., Baig, M. S., Khandelwal, P. N., Kulkarni, S. G., Gade, P. R., and Siddiqui, S. Results of a single blind, randomized, placebo-controlled clinical trial to study the effect of intravenous L-carnitine supplementation on health-related quality of life in Indian patients on maintenance hemodialysis. Cui, G., Xu, W. H., and Wu.G.P. 2014 Feb;99(2):408-22. Malaguarnera, M., Pistone, G., Elvira, R., Leotta, C., Scarpello, L., and Liborio, R. Effects of L-carnitine in patients with hepatic encephalopathy. J Dermatol.Sci 2007;48(2):141-144. Krahenbuhl S. Carnitine metabolism in chronic liver disease. 2009;4(27):45-52. Drugs Exp Clin Res 1991;17:225-35. View abstract. Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. BMC Public Health. Therapeutic Research Faculty 2018. Prev Nutr Food Sci 2020;25(2):124-32. Bohles H, Noppeney T, Akcetin Z, and et al. View abstract. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. 2007;19(2):206-210. A., Gupta, A., Vajifdar, B. U., and Lokhandwala, Y. Y. L-carnitine moderately improves the exercise tolerance in chronic stable angina. Crill, C. M., Storm, M. C., Christensen, M. L., Hankins, C. T., Bruce, Jenkins M., and Helms, R. A. Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Rajasekar, P. and Anuradha, C. V. Effect of L-carnitine on skeletal muscle lipids and oxidative stress in rats fed high-fructose diet. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). Oncologist. Acta Chir Scand Suppl 1983;517:157-164. Segura-Bruna, N., Rodriguez-Campello, A., Puente, V., and Roquer, J. Valproate-induced hyperammonemic encephalopathy. View abstract. Biol Neonate 1990;58:81-8. View abstract. View abstract. Zhonghua Er.Ke.Za Zhi. Sports Med 1996;22:109-32. Clin J Pain 2008;24(8):731-733. 39. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. L-Carnitine: Jim Stoppani Explains The Benefits of Carnitine 2007;25(2):182-188. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. 2006;8(3-4):404-416. 2008;27(3):253-259. Does carnitine cause insomnia? View abstract. 2011;42(3):217-225. Rossini, D., Bulckaen, M., Di, Marco S., Giovannetti, R., Giuntoli, F., Lacopetti, L., and Vergoni, W. [Rehabilitation program in patients with moderate-to-severe intermittent claudication: immediate results and one year follow-up]. How Does Carnitine Support Hashimoto's? - Dr. Izabella Wentz Georgala S, Schulpis KH, Georgala C, Michas T. L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. View abstract. Cochrane.Database.Syst.Rev. Neurology 1991;41:1726-32. Along with its needed effects, levocarnitine (the active ingredient contained in L-Carnitine) may cause some unwanted effects. Am J Med 1993;95:112-3. Nutr Metab Cardiovasc Dis 2019;29(11):1151-67. doi: 10.1016/j.numecd.2019.07.012. Madeddu, C., Dessi, M., Panzone, F., Serpe, R., Antoni, G., Cau, M. C., Montaldo, L., Mela, Q., Mura, M., Astara, G., Tanca, F. M., Maccio, A., and Mantovani, G. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. View abstract. Sabry, A. Scand.J Gastroenterol. View abstract. Rossini, P. M., Marchionno, L., Gambi, D., Pirchio, M., Del Rosso, G., and Albertazzi, A. EMG changes in chronically dialyzed uraemic subjects undergoing d, 1- Carnitine treatment. Jpn Circ.J 1992;56(1):86-94. View abstract. Changes in physical performance of untrained volunteers: effects of L-carnitine. Zhonghua Nan.Ke.Xue. Ann.Hum.Genet. View abstract. 2010;16(3):235-249. Martinotti, G., Andreoli, S., Reina, D., Di, Nicola M., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., and Prof, L. J. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Kang, H. C., Kim, H. D., Lee, Y. M., and Han, S. H. Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency. 2007;178(4 Pt 1):1398-1403. View abstract. View abstract. Oncologist 2010;15:200-11. It can also cause a "fishy" odor of the urine, breath, and sweat. View abstract. View abstract. Healthline Media does not provide medical advice, diagnosis, or treatment. Yeh, Y. Y., Cooke, R. J., and Zee, P. Impairment of lipid emulsion metabolism associated with carnitine insufficiency in premature infants. Eur Heart J 1984;5(Abstr Suppl 1):138. Role of L-carnitine in apnea of prematurity: a randomized, controlled trial. Iranian J.Nutr.Sci.Food Technol. Isidori, A. M., Pozza, C., Gianfrilli, D., and Isidori, A. Raskind JY, El-Chaar GM. 2007;52(6):1774-1775. Gastrointestinal Marti-Carvajal, A. J., Knight-Madden, J. M., and Martinez-Zapata, M. J. View abstract. Geier, D. A., Kern, J. K., Davis, G., King, P. G., Adams, J. Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. Carnitine disposition before and during valproate therapy in patients with epilepsy. 2010;9(3):265-268. View abstract. View abstract. Pesce, V., Fracasso, F., Cassano, P., Lezza, A. M., Cantatore, P., and Gadaleta, M. N. Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis. Int J Sports Med 1996;17(5):320-324. 2009;79(3):131-141. Diabetes Res Clin Pract 1991;14:191-5. Side Effects. Tempesta E, Casella L, Pirrongelli C, et al. Exp.Physiol 2008;93(10):1139-1146. [Effect of L-carnitine in patients with ischemic heart disease]. Insomnia - 10 Medications That Can Cause Sleeplessness - AARP View abstract. Acetyl-L-Carnitine is a potent brain enhancer that can help enhance your learning ability while protecting your brain. Orlandi, A., Francesconi, A., Ferlosio, A., Di, Lascio A., Marcellini, M., Pisano, C., and Spagnoli, L. G. Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit. J Pain Symptom Manage 2006;32:551-9. View abstract. 2008;23(7):1602-1606. Therefore, vegetarians and vegans may want to consider L-carnitine supplements. Maestri, A., De Pasquale, Ceratti A., Cundari, S., Zanna, C., Cortesi, E., and Crino, L. A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. Intern.Med 2010;49(16):1717-1725. Reduce dosage to alleviate this side effect. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. Ma, S. J., Cai, W. W., and Sheng, J. Heller, W., Musil, H. E., Gaebel, G., Hempel, V., Krug, W., and Kohn, H. J. Our website services, content, and products are for informational purposes only. The effect of combined L-carnitine and erythropoietin administration on the anaemia and on the lipid profile of patients on hemodialysis [abstract]. View abstract. View abstract. Rossignol, D. A. View abstract. Beneficial effects of L-carnitine in the reduction of the necrotic area in acute myocardial infarction. Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children. View abstract. An JH, Kim YJ, Kim KJ, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. Silverio, R., Laviano, A., Rossi, Fanelli F., and Seelaender, M. L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. A long-term, randomised, double-blind, placebo-controlled study. l-Carnitine and heart disease - PubMed View abstract. View abstract. J Inherit.Metab Dis 2008;31 Suppl 2:S453-S456. Minerva Anestesiol. View abstract. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Eur J Clin Pharmacol 2019;75(8):1037-46. doi: 10.1007/s00228-019-02666-5. You'll also. View abstract. View abstract. l-Carnitine causes insomnia I've been taking l-Carnitine Fumarate in the evening and it's giving me serious insomnia. Cavallini, G., Ferraretti, A. P., Gianaroli, L., Biagiotti, G., and Vitali, G. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. Sabry, A. Siami, G., Clinton, M. E., Mrak, R., Griffis, J., and Stone, W. Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis. Supplements may also benefit those with lower levels, such as older adults, vegans and vegetarians. Laker MF, Green C, Bhuiyan AK, Shuster S. Isotretinoin and serum lipids: studies on fatty acid, apolipoprotein and intermediary metabolism. Written by Cerner Multum. Carnitine - Health Professional Fact Sheet - National Institutes of Health View abstract. Nefrologia. View abstract. Does L-carnitine reduce belly fat? Improved pallesthetic sensitivity of pudendal nerve in impotent diabetic patients treated with acetyl-L-carnitine. Malaguarnera, M., Vacante, M., Giordano, M., Motta, M., Bertino, G., Pennisi, M., Neri, S., Malaguarnera, M., Li, Volti G., and Galvano, F. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-alpha 2b plus ribavirin. OTHER NAMES(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, OTHER NAME(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, L-carnitine is a chemical that is made in the human. View abstract. Diabetologia 1995;38(1):123. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. According to one study, 5784% of L-carnitine is absorbed when its consumed from food, compared to only 1418% when taken as a supplement (61). Does L carnitine coffee make you lose weight? View abstract. Hemodial.Int. It may also combat diabetes by increasing a key enzyme called AMPK, which improves your bodys ability to use carbs (56). View abstract. Lee, M. S., Lee, H. J., Lee, H. S., and Kim, Y. L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes. View abstract. Eur J Pediatr 1995;154:686-7. J Urol. A single-center prospective pilot study. 2006;44(3):525-530. 244 Jackson Street. Iliceto S, Scrutinio D, Bruzzi P, et al. Immunopharmacol.Immunotoxicol. View abstract. Swiss Med Wkly 2004;134:385. Zhang, X. L. and Ge, H. Clinical observations on treating ischemic cardiomyopathy using Fasudil and L-carnitine. Novak M, Monkus EF, Buch M, and et al. Genger, H., Enzelsberger, H., and Salzer, H. [Carnitine in therapy of placental insufficiency--initial experiences]. Pignatelli, P., Tellan, G., Marandola, M., Carnevale, R., Loffredo, L., Schillizzi, M., Proietti, M., Violi, F., Chirletti, P., and Delogu, G. Effect of L-carnitine on oxidative stress and platelet activation after major surgery. Chinese J.Clin.Healthcare 2008;11(5):478-480. Int.J Sport Nutr.Exerc.Metab 2008;18(1):19-36. View abstract. Fagher, B., Cederblad, G., Eriksson, M., Monti, M., Moritz, U., Nilsson-Ehle, P., and Thysell, H. L-carnitine and haemodialysis: double blind study on muscle function and metabolism and peripheral nerve function. Vitamins & Supplements That Help or Cause Insomnia - ConsumerLab.com The mitochondria act as engines within your cells, burning these fats to create usable energy. Casciani, C. U., Caruso, U., Cravotto, E., Corsi, M., Pola, P., Savi, L., and Grilli, M. Effect of L-carnitine on lipid pattern in haemodialysis. In one study, people who took 3 grams every day for 21 days experienced no negative effects (57). View abstract. Speak with a healthcare provider to find out what dose might be best for a specific condition. Karanth, J. and Jeevaratnam, K. Effect of dietary lipid, carnitine and exercise on lipid profile in rat blood, liver and muscle. The effect of L-carnitine supplement on dialysis patients [abstract]. 2011;17(1):BR1-BR9. Boehm G, Stahl B. Oligosaccharides from milk. Chen N, Yang M, Zhou M, Xiao J, Guo J, He L. L-carnitine for cognitive enhancement in people without cognitive impairment. 2006;29(2):100-107. L-Carnitine as a diet supplement in patients with type II diabetes. Zhang, J. M., Gu, X. F., Shao, X. H., Song, X. Q., Han, L. S., Ye, J., Qiu, W. J., Gao, X. L., Wang, Y., and Wang, M. X. Jpn Heart J 1995;36(3):319-331. L-carnitine is LIKELY SAFE when taken by mouth for up to 12 months, and when used as an injection, with the approval of a healthcare provider. View abstract. L-carnitine is also linked to improvements in patients with severe heart disorders, such as coronary heart disease and chronic heart failure (40, 41). Neuro.Endocrinol.Lett. View abstract. Answer: Supplements including melatonin, tart cherry juice extract, L-tryptophan and 5-HTP, L-theanine, CBD (cannabidiol), ashwagandha, glycine, saffron, valerian, and possibly magnesium or Prevagen may, to varying degrees, improve sleep. View abstract. View abstract. It may not be safe to take this supplement if you have liver or kidney disease, high blood pressure, seizure disorder or diabetes. Biagini, A., Opie, L., Rovai, D., Mazzei, M. G., Carpeggiani, C., and Maseri, A. Ishikura H, Matsuo N, Matsubara M, et al. Shortland, G. J., Walter, J. H., Stroud, C., Fleming, P. J., Speidel, B. D., and Marlow, N. Randomised controlled trial of L-carnitine as a nutritional supplement in preterm infants. Ann.Hematol. Amino.Acids 2012;42(5):1783-1792. This makes L-carnitine a conditionally essential nutrient (6). Cardiovasc.Drugs Ther 2005;19(4):267-275. Effect of L-carnitine on the limitation of infarct size in one-month postmyocardial infarction cases. Sports Med 1996;22:109-32. Cochrane.Database.Syst.Rev. Iranian J.Nutr.Sci.Food Technol. Am J Clin Nutr 1981;34(8):1496-1500. View abstract. Both humans and mice naturally produce acetyl L-carnitine under normal conditions, but studies have shown that some depression-prone animals are deficient in acetyl L-carnitine. Brand names: Carnitor, L-Carnitine View abstract. Clin Trial J 1984;21:40-58. J Clin Lipidology 2012;6:150-158. Int J Clin Pharmacol Res 1990;10:355-60. L-carnitine is a naturally occurring amino acid derivative thats often taken as a supplement. Pryor, J. L., Glass, S. L., Campagnone, J., and Sigman, M. Randomized double blind placebo controlled trial of carnitine for the treatment of idiopathic asthenospermia. View abstract. Chinese J.Pract.Internal Med. View abstract. L-carnitine is the standard biologically active form of carnitine, which is found in your body, foods and most supplements. View abstract. View abstract. View abstract.
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