Is the first-line treatment of keratoacanthomas surgical excision or Also KA's ultimately heal with scarring. The incidence rate in Queensland, Australia is 409/100,000 person-years. Generalised eruptive keratoacanthoma Mascitti H, De Masson A, Brunet-Possenti F, et al. If these are located on the eyelids or nose, tissue in the area can be destroyed. 2014;36(5):4229. After the initial shock, it's human nature for most people to immediately start thinking about worst-case scenarios. doi:10.1007/s13555-021-00502-2. So, if mystery Mohs man teaches you anything (in addition to what the inside of your scalp might look like) it should be this: pay attention to your body. Keratoacanthoma is a common epithelial lesion, but its nature is controversial. However, SCC lumps develop slowly and fail to heal even after several months. Before 1917, keratoacanthoma were regarded as skin cancer. It lasts for two or three months when they grow rapidly and in this phase it can be mixed up with squamous cell carcinoma. Especially in more cosmetically-sensitive areas, and where the clinical diagnosis is reasonably certain, alternatives to surgery may include no treatment (awaiting spontaneous resolution). 2019;9(2):3838. keratoacanthoma is a form of skin squamous cell carcinoma doi: 10.1111/ced.14702 Journal https://onlinelibrary.wiley.com/doi/10.1111/ced.14702. To try and determine if you have a keratoacanthoma lesion, they will ask you a few questions about how the lesion emerged before examining this nodule. Keratoacanthomas often have a thick layer of scale. Generalised eruptive keratoacanthoma is a very rare disease. Mlacker S, Kaw U, Maytin EV. Know about some points of difference between the two. The procedure involves: Once the diagnosis of keratoacanthoma is established, the treatment options usually include: Very rarely, keratoacanthoma are treated with medicine injected directly into the skin lesion (intralesional chemotherapy). This can be true even if the trauma is too small or negligible for the patient. If growing sores or lumps fail to heal, medical assistance should be sought immediately. The lesions may also change into fluid-filled blisters with an ulcer or a horn-like keratin plug developing at their centre. Generalised eruptive keratoacanthoma You may be able to find the same content in another format, or you may be able to find more information, at their web site. Rapidly Recurring Keratoacanthoma | MDedge Dermatology The condition can be accurately diagnosed by pathological examination and biopsy. Scrape off the tumor and seal up the wound. Firstly, it is not always easy for doctors to make sure that a lesion is a keratoacanthoma and not some form of skin cancer. 2015;28(6):799-806. doi:10.1038/modpathol.2015.5. Doctors dont know what causes keratoacanthoma, but some things make you more likely to get it: Your doctor will probably take a biopsy, or a piece of the tumor, to send to an expert called a pathologist, who will examine the sample under a microscope. Keratoacanthoma is a tumor that is seen on a regular basis in a dermatologic and dermato-oncologic practice. Keratoacanthoma. Topical 5-fluorouracil is an effective, convenient, relatively inexpensive treatment for keratoacanthoma that produces excellent cosmetic results. On Wednesday, following the series finale of her TLC television show, Dr. Pimple Popper shared a series of images on social media illustrating the surgery she did on a man with a cancerous growth on his head. The cause of keratoacanthoma is unknown. away. Keratoacanthoma (KA) is a common, rapidly growing, locally destructive skin tumour . Age: predominantly in patients aged 4070 years. Bolognia, Jean L., ed. In rare cases, however, it progresses to metastatic or invasive cases of carcinoma. We review the current management with an emphasis on treatment. They commonly stop growing and slowly shrink away after two months to a year. This technique is especially useful for large rapidly growing KA's. [5][6][7][8], Frequently reported and reclassified over the last century, keratoacanthoma can be divided into various subtypes and despite being considered benign, their unpredictable behaviour has warranted the same attention as with squamous cell carcinoma. List Of Physicians In Duncan, Bc, Christian Mom Group Names, Dahlia Sin Broccoli, Pooh Shiesty Billboard Charts, Popping Keratoacanthoma, Best Bournemouth Uni Accommodation, Vw Shipping From Emden To Uk 2021, 10 Examples Of Osmosis In Our Daily Life, Does Sluggo Kill Earthworms, The Man With The Saxophone By Ai Poem, Domestic Violence Risk Assessment Questionnaire, and then a fully-healed scalp where you can barely see the scar. New York: Mosby, 2003. There is also some controversy over whether keratoacanthoma may be a form of squamous cell carcinoma or may evolve into this. The therapy may be useful in case of large tumors where resection may possible lead to cosmetic disfiguration. popping keratoacanthoma INTRO OFFER!!! Radiation therapy can be applied to the lesion. Gleich T, Chiticariu E, Huber M, Hohl D. Keratoacanthoma: a distinct entity? Keratoacanthoma (KA) is a growth that is relatively common, benign, and most commonly found in elderly light-skinned individuals. Apply liquid nitrogen to freeze and destroy the tumor. Complete excision is the preferred mode of treatment for all skin neoplasms that are suspected to be Keratoacanthoma lesions. KA papules grow rapidly and have a dry core in the middle. [14], If the entire lesion is removed, the pathologist will probably be able to differentiate between keratoacanthoma and squamous cell carcinoma. Most patients are over 60 years of age and it is twice as common in males than in females. The growth may regress on its own, although it may sometimes leave a scar. Keratoacanthoma - Dermatologic Disorders - Merck Manuals Professional Learn how your comment data is processed. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Caueto J, Martn-Vallejo J, Cardeoso-lvarez E, Fernndez-Lpez E, Prez-Losada J, Romn-Curto C. Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma. DermNet does not provide an online consultation service. You are a miracle worker!!!!". DermNet does not provide an online consultation service.If you have any concerns with your skin or its treatment, see a dermatologist for advice. Don't worry, keratoacanthoma is indeed a benign skin tumor and there is no reason to panic. Domed, centrally plugged papules on the face in generalised eruptive keratoacanthomas Patients have an increased incidence of other sun-related skin cancers and should be advised about sun protection and self-examination. [15], Excision of the entire lesion, with adequate margin, will remove the lesion, allow full tissue diagnosis, and leave a planned surgical wound which can usually be repaired with a good cosmetic result. http://www.patient.co.uk/doctor/Keratoacanthoma.htm, http://ratguide.com/health/neoplasia/keratoacanthoma.php, http://emedicine.medscape.com/article/1100471-overview, http://www.nlm.nih.gov/medlineplus/ency/imagepages/2308.htm. 2014;54(2):1607. Note that this may not provide an exact translation in all languages, Home 2016;74(6):122033. High-risk features for local recurrence and the development of metastatic disease include >2 mm thickness; Clark level higher than IV; perineural invasion; lip or ear as primary site; poorly or undifferentiated tumor. Keratoacanthoma (KA) is a cutaneous tumor that most commonly presents as a dome-shaped nodule with a central keratin-filled crater ( picture 1A-E) [ 1 ]. The scar gradually fades to result in a more acceptable cosmetic appearance. Dr. Pimple Popper Posts Bloody Skin Cancer Hole In New Instagram However, removing the entire lesion (especially on the face) may present difficult problems of plastic reconstruction. The fact is that there is controversy over whether keratoacanthoma is a unique non-cancerous lesion that can resolve on its own or is a form of cancer. Generalised eruptive keratoacanthomas. The lesion is then cut out using an elliptical hand movement that ensures its complete removal. As such, the recognition of the true nature . Let us read about what hard lumps are, what causes them, how to treat them, and when you should see a doctor. It is not associated with internal malignancy, except in rare instances where multiple keratoacanthomas are associated with a disease process called Muir-Torre syndrome. Depending on the site of involvement, keratoacanthoma may interfere with normal function of the affected area. Definition / general. This image displays a keratoacanthoma, a form of skin cancer, that needs a biopsy by a dermatologist and full removal. She even subtyped it as keratoacanthoma type of squamous cell carcinoma, which is a very fast-growing and aggressive cancer. Typical to keratoacanthomas, this lesion is red and inflamed at the base. A keratoacanthoma is a type of skin cancer, a squamous cell carcinoma, which is not life threatening at this size but can certainly grow rather quickly and can therefore be scary to the patient. With a keratoacanthoma, you develop a red bump or dome on your skin that may resemble a horn. A common and distinctive feature of KA is a clinical course characterized by phases of rapid growth, lesion stability, and spontaneous involution. She has a masters degree in journalism from Northwestern University, lives in New York City, and dreams of becoming best friends with Ina Garten, who is, undeniably, an absolute queen. 1995;36(2):83-85. doi:10.1111/j.1440-0960.1995.tb00938.x. [1], Keratoacanthomas may be divided into the following types:[9]:763764[10]:643646, Keratoacanthomas usually occurs in older individuals. The lesions can arise as an effect of sun-exposure. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) rapidly-growing skin tumour that is believed to originate from the hair follicle (pilosebaceous unit) and can resemble squamous cell carcinoma. A clinical and biological review of keratoacanthoma. Keratoacanthoma. He is a clinical professor at the University of Colorado in Denver, and co-founder and practicing dermatologist at the Boulder Valley Center for Dermatology in Colorado. BRB, gagging, but also can't. JAAD Case Rep. 2017;3(5):4579. Keratoacanthoma (KA) is a well differentiated, cutaneous squamous cell carcinoma, which often spontaneously regresses. These lesions may start as a small bump of 1 to 2 millimeters in size and rapidly grow to be 1 to 3 centimeters over a one- to two-month period. Proper diagnosis and timely treatment can help you avoid discomforting symptoms as well as potential cancerous complications from this disorder. Maxine Lipner is a long-time health and medical writer with over 30 years of experience covering ophthalmology, oncology, and general health and wellness. Keratoacanthoma (KA) is a skin condition that gives rise to discomforting sores on the body and may also cause cancer. The keratoacanthoma: a review - PubMed [14], On the trunk, arms, and legs, electrodesiccation and curettage often suffice to control keratoacanthomas until they regress. In fact, the diagnosis and categorization of KA is a controversial topic among dermatologist. Most keratoacanthoma cause only minimal skin destruction, but a few behave more aggressively and can spread to lymph nodes. Following this, the region usually heals quickly. It grows rapidly, reaching a large size within days or weeks, and if untreated for months will almost always starve itself of nourishment, necrose (die), slough, and heal with scarring. .css-26w0xw{display:block;font-family:NationalBold,Helvetica,Arial,Sans-serif;font-weight:bold;margin-bottom:0;margin-top:0;-webkit-text-decoration:none;text-decoration:none;}@media (any-hover: hover){.css-26w0xw:hover{color:link-hover;}}@media(max-width: 48rem){.css-26w0xw{font-size:1.18581rem;line-height:1.2;margin-bottom:0.625rem;}}@media(min-width: 40.625rem){.css-26w0xw{line-height:1.2;}}@media(min-width: 48rem){.css-26w0xw{font-size:1.28598rem;line-height:1.2;margin-bottom:0rem;}}@media(min-width: 64rem){.css-26w0xw{font-size:1.575rem;line-height:1.1;margin-bottom:-0.5rem;}}These Bidets Will Keep Your Butt Happier Than Ever, This Is The World We Live In, We Live With MS, These Healthy Habits of the Royals Are Worth Steal, Find Your Purpose In Life In 3 Easy Steps, How One Woman Takes Control Of Her Life With MS, Say Goodbye To Those Ingrown Hairs On Your Vulva, 'I Tried This Stress-Relief Device For 30 Days', Sweaty Sleepers Need These Mattress Toppers, 3 Bladder Health Myths You Need to Stop Believing, Here's Everything Jenna Bush Hager Eats In A Day, How To Talk To Your Doc About Your Bathroom Habits. Preventing sun damage is crucial to avoiding the development of keratoacanthoma: If left untreated, most keratoacanthoma spontaneously disappear (resolve) within 6 months, leaving a depressed scar. Removal (excision), in which the doctor uses a knife-like instrument (scalpel) to cut out the keratoacanthoma and then place stitches to bring the wound edges together. This image displays a cup-like shape with a thick "plug" of scaly skin typical of keratoacanthomas. 2010; 32(5):4236. The disorder can be managed with the aid of oral medicines like Cyclophosphamide, Methotrexate or Acitretin. Irreversible blindness in generalised eruptive keratoacanthoma of Grzybowski. "Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is believed to originate from the neck of the hair follicle. arrow-right-small-blue The lesion starts as a small, round, flesh-colored or red bump, and then grows rapidly on the skin from 1-2mm to 1-3cm over a few weeks. English (US) Pages (from-to) 82-85. Use of photodynamic therapy and acitretin in generalized eruptive keratoacanthoma of Grzybowski. Most keratoacanthoma are painless, though some may be itchy. Squamous cell carcinoma treatment. Follow-up would be required to monitor for recurrence of disease. ACD A-Z of Skin - Keratoacanthoma It was first described in 1950 and around 40 cases have been reported since. It is uncommon in young adults, darker-skinned patients and Japanese people. But even though these growths are non-cancerous themselves, these are often confused with lesions appearing due to an underlying squamous cell carcinoma. Keratoacanthoma is a dome-shaped lump or tumor that grows on your skin. It often starts in a hair follicle. Keratoacanthoma and squamous cell carcinoma are distinct from a It starts in skin cells that surround the hair follicle. Hyperkeratotic lesions on the legs in generalised eruptive keratoacanthomas Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter (called a punch biopsy). The electrodesiccation helps to kill the cancer cells and also to stop any bleeding at the site. Facebook - National Cancer Institute Podophyllin resin, methotrexate intralesional injections, and radiotherapy are effective for giant KA's. The most effective and most practical treatment may be oral acitretin. WebMD does not provide medical advice, diagnosis or treatment. Keratoacanthoma usually range in size from 12.5 cm. Mohs micrographic surgery, in which the physician takes tiny slivers of skin from the cancer site until it is completely removed. 2014;53(2):1316. This image displays a close-up of a keratoacanthoma. Middle-aged and older adults with fair complexions are most frequently affected [ 2 ]. Excellent results have been reported with 5-fluorouracil injections. The disease may also occur due to carcinogens (chemical substances that give rise to cancer). Epidermolytic acanthoma: a case report. Skin biopsy in the diagnosis of neoplastic skin disease Men are twice as likely to have the condition as women. In the center, it has a keratin core (the protein that forms your nails and hair). 2010; 28(3):25461 (, Kossard S; Tan KB; Choy C; Keratoacanthoma and infundibulocystic squamous cell carcinoma. (On the nose and face, Mohs surgery may allow for good margin control with minimal tissue removal, but many insurance companies require the definitive diagnosis of a malignancy before they are prepared to pay the extra costs of Mohs surgery.) Its rare for anyone under age 20 to have keratoacanthoma. The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Keratoacanthoma (KA) is a common, rapidly growing, locally destructive skin tumour. Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). A pathological examination may reveal the presence of squamous cell carcinoma where a dermatological test shows a keratoacanthoma lesion. While there are always some very loud haters on social media, lots of the comments on Dr. Pimple Popper's post are applauding her A+ job: "Amazing work as always," "Wow. But only some see this as a distinct lesion. Topical 5-fluorouracil cream applied three times a day for 1 to 6 weeks has been found to be effective. Keratoacanthomas are sharply demarcated, firm, erythematous or skin-coloured, with a classic central hyperkeratotic plug and an even shoulder. It was first described in 1950 and around 40 cases have been reported since. By Maxine Lipner thurgood marshall school of law apparel Projetos; bubble buster 2048 town Blog; cell defense the plasma membrane answer key step 13 Quem somos; how to make a good elder scrolls: legends deck Contato It is uncommon in young adults, darker-skinned patients and Japanese people. It is also effective for removal of lesions that recur even after attempted excision. There can be so many that doctors cant remove them all with surgery. Keratoacanthoma a cutaneous low-grade tumor More common in middle-aged and elderly individuals [6] Muir-Torre syndrome Rapid growth (within 2-3 months) in areas of skin exposed to the sun (e.g., the ears) Lesion: round dome-shaped, erythematous nodule with central crater Histology: central, hyperkeratotic crater surrounded by squamous epithelium doi:10.1111/ijd.12318. It is characterized by the growth of lesions that can sometimes be as many as hundred or more in number. But Dr. Pimple Popper explains that this "squamous cell carcinoma"which commonly appears on sun-exposed areas of the body, according to American Cancer Societyis actually "not life threatening at this size but can certainly grow rather quickly and can therefore be scary to the patient." The differential diagnosis of Keratoacanthoma mainly involves detecting the presence of the disease as well as ruling out other conditions like: It is also necessary to distinguish it from any form of skin cancer. Other possible causes can include: You may visit your healthcare provider when you note symptoms of keratoacanthoma, and they may refer you to a dermatologist (a specialist in skin conditions). Keratoacanthoma. 1993. pp. Numbing the skin with an injectable anesthetic. Keratoacanthomas must be distinguished from well-differentiated SCC. This is called. Keratoacanthoma - Pictures, Symptoms, Diagnosis, Complications By Admin. Risk factors for the development of keratoacanthoma include: The most common locations for keratoacanthoma include: A keratoacanthoma appears and grows rapidly over the course of 26 weeks. Generalised eruptive keratoacanthoma: a diagnostic and therapeutic challenge. Wear wide-brimmed hats and long-sleeved shirts. Verywell Health's content is for informational and educational purposes only. doi:10.1111/1346-8138.12104. Different types of keratoacanthoma includeacantholytic, clear cell, epidermolytic, and melanoacanthoma. You can have the procedure in your doctors office with medicine to numb the area around the tumor. Skin Cancer Foundation: Squamous Cell Carcinoma., American Academy of Dermatology: Squamous Cell Carcinoma., DermNet New Zealand: Keratoacanthoma, Multiple Self-Healing Squamous Epitheliomas of Ferguson-Smith, Grzybowski Generalized Eruptive Keratoacanthomas.. Norgauer J, Rohwedder A, Schaller J, et al. Gavish is an award-winning freelance medical and health writer and editor with 15 years of experience. Remove one layer of tissue at a time and examine each one under a microscope to make sure all abnormal cells are gone. The accurate management of this tumor is the biggest challenge. Keratoacanthoma is a squamoproliferative lesion of unknown cause that occurs chiefly on sun-exposed skin and, far less commonly, at the mucocutaneous junction. doi:10.1016/j.jaad.2015.11.033. It is also referred to as Pseudocarcinoma. Most cases are seen in older adults. 1-3 They are described as progressing through 3 clinical stages: rapid proliferation, mature/stable, and involution. Its similarity in appearance with more aggressive forms of skin cancer often causes it to be misdiagnosed. Journal of Investigative Dermatology: Are Keratoacanthomas Variants of Squamous Cell Carcinomas? It should be added to the therapeutic armamentarium of all physicians who treat keratoacanthoma. Although the exact cause is not known, sun exposure is thought to be involved in the development of keratoacanthoma lesions. Ko CJ, Keratoacanthoma: facts and controversies. However, an antimicrobial ointment may provide soothing sensations if the adjacent tissue is found to be irritated, inflamed or cracked. It is not associated with internal malignancy, except in rare instances where multiple keratoacanthomas are associated with a disease process called, Roger C. Byrd, DO Clinical Manuscript Competition, Dermatopathology of Summer Skin Conditions, Update on Eczema: Focus on Atopic Dermatitis, 2022 Fall Conference Newsletter Is Available, AOCD Board of Trustees Pens Letter to ABD Regarding Certification Recognition, AOCD Thursday Bulletin for September 16, 2021, AOCD Thursday Bulletin for August 12, 2021, AOCD 2024 Spring New Trends in Dermatology, AOCD 2025 Spring New Trends in Dermatology. Squamous cell is more dangerous than basal cell, and early diagnosis and treatment are best. 2013;4(2):119-121. doi:10.4103/2229-5178.110638. 2018;43(8):876-882. doi:10.1111/ced.13570. A dermatofibroma is a hard bump that generally forms on an arm or leg in a spot where the skin has been damaged in some way (perhaps bitten by a bug or stuck by a thorn), but in many cases, it's. Certain nodules of this type seem to be associated with Human Papilloma Virus (HPV) infection, which also gives rise to warts. Because it may be unclear whether the lesion is a squamous cell carcinoma and may spread, this should either be removed or destroyed with surgery, cryotherapy, radiation, and other procedures. Keratoacanthoma is most common in fair-skinned older males with a history of chronic sun exposure. Keratoacanthoma Condition, Treatments and Pictures for Adults Clin Dermatol. It is more common with individuals having an increased degree of sun exposure and is often found at sites of previous injury or trauma. The base of the nodule is then cauterized with equipment that resembles a soldering iron. Unfortunately, dermoscopy cannot reliably discriminate KA from SCC. They can: If you cant have surgery, or if you have multiple keratoacanthomas, you can try other treatments: Its not unusual for a single keratoacanthoma to shrink and disappear on its own after several months. Hearst Magazine Media, Inc. All Rights Reserved. Keratoacanthoma (Squamous cell carcinoma of the keratoacanthoma type Removal of the keratotic core will leave a crater-like appearance to the lesion. Having the skin sample examined under the microscope by a specially trained physician (dermatopathologist). Generalized eruptive keratoacanthomas of Grzybowski. The classic keratoacanthoma has a crateriform appearance when viewed histologically at low power. Try to remember to tell your doctor when you first noticed the lesion and what symptoms, if any, it has. This is a painless treatment that causes lesions to form into scabs which fall off after a few weeks. Treatment is often unsatisfactory. Keratoacanthoma (KA) is a low-grade, rapidly growing, 1 to 2 cm dome-shaped skin tumor with a centralized keratinous plug. Histologic subtypes include spindle-cell, acantholytic, verrucous, and desmoplastic SCCs, and keratoacanthoma. It sometimes happens to people before they get squamous cell. Keratoacanthoma. Keratoacanthoma (KA) is a relatively common type of skin cancer . The treatment of Keratoacanthomas involves use of. Dermatol Ther (Heidelb). If you develop a keratoacanthoma, a bump or dome with a central core has appeared somewhere on your skin. Shave biopsy of keratoacanthoma only helps reveal keratin fragments. Keratoacanthoma (KA) is a common but underreported tumor of the skin. Once it reaches a maximum size, it generally destroys itself over some more months. Once youve had one keratoacanthoma, you may be more likely to get others in the future. The growths may spread throughout the body (metastasise) and become locally aggressive. This can cause as many as 100 keratoacanthomas at one time. Identifying & Treating Skin Cancer on the Face, When to Worry vs. Not Worry About Lumps Under Your Skin, Pictures of Actinic Keratosis, Moles, Nevus, and Psoriasis, Clear cell acanthoma: a review of clinical and histologic variants, Melanoacanthoma: uncommon presentation of an uncommon condition, Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective, Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma. Avoid ultraviolet (UV) light exposure from natural sunlight or from artificial tanning devices. Canker Sore vs. Cancer: What Are the Differences? Note that this may not provide an exact translation in all languages, Home It is not intended nor implied to be a substitute for professional medical advice and shall not create a physician - patient relationship. Systemic retinoids (such as Isotretinoin), 5-fluorouracil, steroids, bleomycin and intralesional methotrexate have been found to yield some success in treating the condition. Derms like Dr. Pimple Popper know best, so it never hurts to get their eyes on whatever's caught your attention as well. DB's Pilar Cyst Removal! This technique is particularly useful for keratoacanthoma located on the nose, the ears, the lips, and the hands. Some also think that acanthoma is a variant of squamous cell carcinoma. It most frequently occurs on the sun exposed skin of the head and neck, arms and legs and is more common in fair sun-damaged individuals or people whose immune system is suppressed by disease or treatment (such as transplant patients). Some possible causes of Keratoacanthoma are: Exposure to sunlight plays a vital role in the development of this condition. Age: predominantly in patients aged 40-70 years. The AOCD limits permission for downloading education material for personal use only. Grzybowski generalized eruptive keratoacanthoma: Complete Overview 2020;156(12):132432. [2][3] It is rarely found at a mucocutaneous junction or on mucous membranes.